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Showing posts from April, 2020

The bloody war of 2020

Today, the SARS-CoV-2 has spread to about 210 countries with close to 3 million active cases. Of those cases that have obtained an outcome, 81% of the patients have recovered but the remaining have failed to survive the dreaded coronavirus pandemic. It has been observed that patients aged over 65 years, those with lowered immunity or any chronic diseases such as diabetes and hypertension are more susceptible to death caused due to COVID-19. Of the active cases today, about 3% face severity in the symptoms of the illness and are moved to critical units for observation and recovery. Although these numbers provide us with a general trend to analyse the nature of infection by the virus, it is not accurate and does not entirely provide the actual picture. Reasons for this include insufficient testing, non-inclusion of fatalities without testing, scenarios where governments refrain from testing or providing information and also specific cases like the incorrect number of cases reported ...

Understanding SARS-CoV-2: structure, mechanisim and medication

The nCoV-19 (SARS-CoV-2) is much like a warrior that mother nature has begotten to reclaim what her child has been plundering. She doesn't need to do it, but every now and then he forgets his place. He is mankind, her dearest child of all creation that is more brilliant and ferocious than any other. He realises that he has lost the battle, but its time to win the war. The war against the deadly virus and a cure to heal them all.  Let's get down to the science. This virus comes armed with a lethal trimeric spike protein that interferes with porphyrin in RBCs. The membrane of this virus packs envelope proteins that aid in shielding the RNA within. The RNA codes for a protease that is involved in active replication within host cells. Thanks to leaps in technology we already have solved crystal and Cryo-EM structures of the protease and its spike protein. A detailed list of all their structures can be found here . Several researchers have studied the morphology of infected ho...